Verdict: Justified
Since last dive
- Dive #16 (10/8/2026): verdict mixed at $68.13. At that point the stock was -18% in 3 sessions inside an AI-bio theme flush, with no company news.
- Since then: a low of $61.51 (10/22), a theme rebound on Anthropic's AI-drug-discovery news (10/27-28), and now the Q3 report (11/2, before the open). Price $68.13 → ~$81.60 (+19.8%).
- What changed: this move has a real company catalyst (profit beat, data growth, a 2027 pricing step-up). The 10/8 call judged a news-less flush, so the question is new. The verdict moves from mixed to justified.
Key finding: A profit beat on in-line revenue. Q3 revenue was $411.5M (+23%), about in line with the ~$409.4M consensus. Adjusted EBITDA jumped to $25.6M from $1.5M, and adjusted EPS was $0.07 vs a consensus loss. Data & Applications grew +33% with >$550M of data licensing bookings year to date (including a new BMS deal), and new xT pricing adds ~$80M of oncology revenue from 1/1/2027. The full-year revenue guide was nudged up only at the low end ($1.60-1.605B). The stock is +13.0% intraday on above-average volume.
Scorecard
| Ticker | Rev last Q ($M) | Rev YoY last Q | Rev YoY prior Q | Gross margin (last Q, trend) | Op margin | EPS last Q vs yr ago | P/S | Mkt cap | 1-mo price % |
|---|---|---|---|---|---|---|---|---|---|
| TEM | 411.5 | +23.1% | +21.6% | 64.8% (from 64.5%) | -13.8% | -0.08 vs -0.46 | 9.6 | $14.4B | -11.8% |
| NTRA | 752.8 | +37.7% | +38.8% | 64.5% (from 64.8%) | -10.1% | -0.47 vs -0.74 | 20.7 | $56.1B | +0.2% |
| GH | 335.0 | +44.3% | +48.3% | 65.4% (from 65.2%) | -38.6% | -0.90 vs -0.80 | 19.5 | $23.0B | +0.2% |
| CAI | 263.7 | +45.4% | +78.8% | 68.1% (from 65.4%) | +10.2% | -0.00 vs -1.87 | 9.4 | $9.3B | +12.1% |
EPS = GAAP. TEM = September quarter (reported 11/2); NTRA, GH and CAI rows are their June quarter. 1-mo = 9/30 to 10/30 close (before TEM's report-day move). TEM P/S uses trailing revenue including Q3 and today's market cap.
TEM is the cheap, slower-growing name of the group: revenue +23% vs +38-45% for NTRA, GH and CAI, but 9.6x sales vs ~20x for NTRA and GH.
- The operating loss is narrowing (-13.8% vs -18.3% a year ago). CAI is the only one with a positive operating margin.
- TEM trades at about CAI's multiple while CAI grows twice as fast.
Move
- 11/2 (report day, released before the open): prior close $72.22, open $74.31 (gap +2.9%), early low $70.30 (-2.7%), then up to a high of $81.72. About $81.60 (+13.0%) at 12:18 ET on 8.2M shares, already ~1.2x the 50-day average (6.98M) by midday.
- 2026 path: $40.77 low (7/28) → $89.09 high (9/29) = +118% → $61.51 low (10/22) = -31% → ~$81.60 now. The 52-week high is $90.53 (11/3/2025).
- AI-bio theme swings: 10/6 -12.5% (theme flush, no company news); 10/27-28 about +14% in two sessions (Anthropic AI-drug news).
- Above the 50-day ($70.69) and the 200-day ($56.94).
Catalyst
Q3 2026, released 11/2 before the open (8-K):
- Revenue $411.5M (+23%) vs ~$409.4M consensus (in line).
- Diagnostics $303.5M (+20%): oncology volume +32%, Hereditary revenue +3%. MRD volume ~12,000 tests (+300%).
- Data & Applications $108.1M (+33%); Insights +29%.
- Gross margin 64.8% (vs 62.8%). GAAP operating loss -$56.9M (vs -$61.0M). Net loss -$14.9M (vs -$80.0M), helped by $42.8M of unrealized gains on securities.
- Adjusted EBITDA $25.6M (vs $1.5M). Adjusted EPS $0.07; consensus was a loss (FMP -$0.09; Investing.com cites +$0.01).
- Data bookings >$550M year to date: BMS oncology data and models up to $137.5M over 5 years; Pathos AI Alzheimer's data $55M over 5 years.
- FY26 guide: revenue raised to $1.60-1.605B (~25% growth; the low end was $1.595B); adjusted EBITDA ~$65M (unchanged).
- 2027: new xT pricing from 1/1/2027 adds ~$80M of oncology ASP uplift (more if xF gets FDA approval). MRD gross profit per test may turn positive ~mid-2027. Management targets 25%+ annual growth and reinvests about two-thirds of incremental gross profit.
- Also: two FDA 510(k) clearances (ECG-PH, ECG-MR); the Personalis acquisition cleared regulatory review (Personalis vote 11/30); a Merck/Moderna collaboration on an individualized neoantigen therapy.
Sector
- AI-drug discovery / AI-bio is a hot, crowded theme. The group moves together and in both directions: -12.5% (10/6) and about +14% in two days (10/27-28) on Anthropic's AI-drug news.
- Diagnostics peers trade richer: NTRA and GH at ~20x sales vs TEM 9.6x. XBI 155.98 (10/30), -1.1% over the month.
Risks
- Related-party revenue: Pathos AI paid $22.1M in Q3 (~20% of Data & Applications) plus the new $55M deal. Tempus's founder and CEO is a co-founder and the executive chairman of Pathos (10-Q).
- Stock comp: $50.8M in Q3 (~12% of revenue); nine-month stock comp $154.9M vs $79.4M a year ago.
- Debt: convertible notes $1.17B (vs $728M at the end of 2025) plus a $176M convertible note; cash and securities $854M.
- Personalis deal (vote 11/30) initially adds losses.
- Hereditary grew only 3%. The guide raise was tiny and adjusted EBITDA guidance was unchanged.
- Theme volatility: AI-bio names swing ±10%+ on theme news with no company news.
Judgement
Justified. The move rests on a real profit turn (adjusted EBITDA $25.6M vs $1.5M, a positive adjusted EPS vs an expected loss), +33% data growth with >$550M of bookings, and visible 2027 upside (~$80M xT pricing). Revenue was only in line and the guide barely moved, so this is a profitability and visibility re-rating, not a revenue surprise. Even after the move, TEM trades at about half the sales multiple of NTRA and GH. Watch the related-party data revenue (Pathos) and the stock comp.
Sources
- https://www.sec.gov/Archives/edgar/data/0001717115/000119312526442619/tem-ex99_1.htm
- https://www.marketbeat.com/instant-alerts/transcript-what-tempus-ai-tem-said-on-its-q3-earnings-call-2026-11-02/
- https://www.investing.com/news/transcripts/earnings-call-transcript-tempus-ai-beats-q3-2026-eps-forecast-lifts-outlook-93CH-4992054
- https://www.gurufocus.com/news/9162046/tempus-ai-tem-posts-strong-q3-results-raises-2026-revenue-guidance-amid-mixed-valuation-signals
- https://fourweekmba.com/ai-tempus-lifts-2026-revenue-guide-to-1-6b-data-unit-up-33/
- Prices and fundamentals: bullishagent prices_daily / fundamentals_quarterly / FMP quote and earnings calendar