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Portfolio (Quarterly) Guide ↗

RTW INVESTMENTS, LP

· CIK 0001493215
13F Portfolio $10.0B AUM Filed Feb 17, 2026 EDGAR ↗ ← All Funds
Q1 2026 Q4 2025 · All 91 New
Page 2 of 5  ·  91 positions
# Ticker Company Sector Shares Value ↓ % Port Chg Shares Chg % Period Price ① Since Period ①
21 GH GUARDANT HEALTH INC Healthcare 1,481,033.0 $151.3M 1.51% NEW $102.14 +26.4%
22 NBIX NEUROCRINE BIOSCIENCES INC Healthcare 1,062,072.0 $150.6M 1.51% NEW $141.83 +12.1%
23 SYRE SPYRE THERAPEUTICS INC Healthcare 4,171,996.0 $136.7M 1.37% NEW $32.76 +167.1%
24 ZLAB ZAI LAB LTD Healthcare 6,959,032.0 $122.8M 1.23% NEW $17.64 +0.5%
25 IMTX IMMATICS N.V Healthcare 11,433,354.0 $120.1M 1.20% NEW $10.50 -9.3%
26 BLTE BELITE BIO INC Healthcare 715,332.0 $114.4M 1.15% NEW $159.96 -7.3%
27 URGN UROGEN PHARMA LTD Healthcare 4,543,895.0 $106.4M 1.07% NEW $23.42 +40.1%
28 XNCR XENCOR INC Healthcare 6,777,461.0 $103.8M 1.04% NEW $15.31 -20.3%
29 PODD INSULET CORP Healthcare 324,600.0 $92.3M 0.92% NEW $284.24 -49.5%
30 TSHA TAYSHA GENE THERAPIES INC Healthcare 16,398,297.0 $90.2M 0.90% NEW $5.50 +12.5%
31 MASI MASIMO CORP Healthcare 683,294.0 $88.9M 0.89% NEW $130.06 +38.4%
32 QURE UNIQURE NV Healthcare 3,711,462.0 $88.8M 0.89% NEW $23.93 +101.3%
33 SYK STRYKER CORPORATION Healthcare 245,000.0 $86.1M 0.86% NEW $351.47 -14.3%
34 CGON CG ONCOLOGY INC Healthcare 2,012,127.0 $83.5M 0.84% NEW $41.52 +45.5%
35 CSTL CASTLE BIOSCIENCES INC Healthcare 2,115,237.0 $82.3M 0.82% NEW $38.90 -47.9%
36 IMVT IMMUNOVANT INC Healthcare 3,177,850.0 $80.8M 0.81% NEW $25.42 +36.5%
37 BBNX BETA BIONICS INC Healthcare 2,500,000.0 $76.2M 0.76% NEW $30.47 -56.7%
38 GHRS GH RESEARCH PLC Healthcare 5,933,815.0 $75.4M 0.76% NEW $12.70 +70.9%
39 REPL REPLIMUNE GROUP INC Healthcare 7,140,352.0 $69.4M 0.69% NEW $9.72 +2.9%
40 RARE ULTRAGENYX PHARMACEUTICAL IN Healthcare 3,000,139.0 $69.0M 0.69% NEW $23.00 +17.0%
Page 2 of 5  ·  91 positions

Period Price is the implied market price on the last day of the reporting period, calculated as reported value ÷ shares held. It is not the fund's purchase price or cost basis — the fund may have initiated or added to the position at any point during the quarter at a different price. Since Period shows the price change from that quarter-end snapshot to today's last price — it reflects stock movement after the report date, not the fund's actual return.

Sector Allocation
Healthcare 100.0%