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Portfolio (Quarterly) Guide ↗

Siren, L.L.C.

· CIK 0002005245
13F Portfolio $4.9B AUM 119 positions Filed Aug 13, 2026 EDGAR ↗ ← All Funds
Q2 2026 · All 117 New
Page 3 of 6  ·  117 positions
# Ticker Company Sector Shares Value ↓ % Port Chg Shares Chg % Period Price ① Since Period ①
41 TRVI Trevi Therapeutics Inc Healthcare 1,786,867.0 $33.3M 0.67% NEW — $18.65 -25.4%
42 ORIC Oric Pharmaceuticals Inc Healthcare 2,998,192.0 $32.5M 0.66% NEW — $10.83 +12.7%
43 GOOGL Alphabet Inc Communication Services 90,000.0 $32.2M 0.65% NEW — $357.37 -3.9%
44 — Dbv Technologies SA — 1,857,362.0 $30.5M 0.62% NEW — $16.40 —
45 ABSI Absci Corp Healthcare 2,474,764.0 $28.7M 0.58% NEW — $11.59 -4.5%
46 SION Sionna Therapeutics Inc Healthcare 610,515.0 $26.9M 0.54% NEW — $43.99 -88.8%
47 RAPP Rapport Therapeutics Inc Healthcare 641,469.0 $26.7M 0.54% NEW — $41.67 -22.8%
48 AMLX Amylyx Pharmaceuticals Inc Healthcare 1,480,586.0 $26.6M 0.54% NEW — $17.96 +54.7%
49 ANNX Annexon Inc Healthcare 4,458,646.0 $25.5M 0.52% NEW — $5.71 -26.6%
50 — Monopar Therapeutics Inc — 270,118.0 $25.0M 0.51% NEW — $92.59 —
51 ORKA Oruka Therapeutics Inc Healthcare 250,000.0 $23.8M 0.48% NEW — $95.17 -11.2%
52 — Seaport Therapeutics Inc — 1,095,316.0 $23.8M 0.48% NEW — $21.72 —
53 — Damora Therapeutics Inc — 900,000.0 $23.4M 0.47% NEW — $26.01 —
54 TYRA Tyra Biosciences Inc Healthcare 725,000.0 $23.2M 0.47% NEW — $31.94 -36.0%
55 — Zura Bio Ltd — 3,734,866.0 $22.0M 0.45% NEW — $5.90 —
56 TSM Taiwan Semiconductor Manufacturing Co Ltd Technology 44,700.0 $21.3M 0.43% NEW — $477.57 -1.0%
57 NVDA NVIDIA Corp Technology 95,000.0 $19.0M 0.39% NEW — $200.09 +16.9%
58 RZLT Rezolute Inc Healthcare 3,328,287.0 $17.3M 0.35% NEW — $5.20 -22.9%
59 MPLT MapLight Therapeutics Inc Healthcare 450,000.0 $16.1M 0.33% NEW — $35.84 -72.6%
60 NMRA Neumora Therapeutics Inc Healthcare 8,497,822.0 $14.4M 0.29% NEW — $1.70 -70.6%
Page 3 of 6  ·  117 positions

① Period Price is the implied market price on the last day of the reporting period, calculated as reported value ÷ shares held. It is not the fund's purchase price or cost basis — the fund may have initiated or added to the position at any point during the quarter at a different price. Since Period shows the price change from that quarter-end snapshot to today's last price — it reflects stock movement after the report date, not the fund's actual return.

Sector Allocation
Healthcare 92.4%
Technology 3.9%
Communication Services 1.8%
Financial Services 1.3%
Consumer Cyclical 0.6%
Real Estate 0.0%