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Portfolio (Quarterly) Guide ↗

Opaleye Management Inc.

· CIK 0001595855
13F Portfolio $758M AUM 54 positions Filed Apr 13, 2026 EDGAR ↗ ← All Funds
Q4 2025 Q3 2025 · All 21 New 14 Added 7 Reduced 10 Exited
# Ticker Company Sector Shares Value ↓ % Port Chg Shares Chg % Period Price ① Since Period ①
1 APOGEE THERAPEUTICS INC 388,257.0 $29.3M 3.87% +25K +6.9% $75.48
2 STOK STOKE THERAPEUTICS INC Healthcare 695,000.0 $22.1M 2.91% +13K +1.9% $31.74 -8.5%
3 SLGL SOL GEL TECHNOLOGIES Healthcare 453,739.0 $19.1M 2.52% +249K +121.5% $42.14 +50.2%
4 DISC MEDICINE INC 200,000.0 $15.9M 2.10% +6K +3.2% $79.41
5 RZLT REZOLUTE INC Healthcare 6,287,156.0 $14.8M 1.96% +5.4M +595.9% $2.36 +37.3%
6 ALKS ALKERMES PLC Healthcare 490,000.0 $13.7M 1.81% +40K +8.9% $27.98 +32.2%
7 ALPHA COGNITION INC 2,070,784.0 $13.5M 1.78% +2.0M +1698.5% $6.50
8 MBX MBX BIOSCIENCES INC Healthcare 260,000.0 $8.2M 1.08% +7K +2.8% $31.54 -1.8%
9 XOMA XOMA CORP DEL Healthcare 292,590.0 $7.8M 1.03% +38K +14.7% $26.59 +56.6%
10 RIGL RIGEL PHARMACEUTICALS INC Healthcare 70,000.0 $3.0M 0.40% +32K +85.2% $42.83 -33.2%
11 ZYMEWORKS INC 108,929.0 $2.9M 0.38% +9K +8.9% $26.33
12 OPUS GENETICS INC 1,120,000.0 $2.3M 0.30% +20K +1.8% $2.01
13 CABA CABALETTA BIO INC Healthcare 900,000.0 $2.0M 0.26% +91K +11.3% $2.19 +49.3%
14 ZNTL ZENTALIS PHARMACEUTICALS INC Healthcare 1,400,906.0 $1.9M 0.25% +1.1M +342.6% $1.35 +168.9%

Period Price is the implied market price on the last day of the reporting period, calculated as reported value ÷ shares held. It is not the fund's purchase price or cost basis — the fund may have initiated or added to the position at any point during the quarter at a different price. Since Period shows the price change from that quarter-end snapshot to today's last price — it reflects stock movement after the report date, not the fund's actual return.

Sector Allocation
Healthcare 100.0%