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Portfolio (Quarterly) Guide ↗

Opaleye Management Inc.

· CIK 0001595855
13F Portfolio $757.9B AUM 54 positions Filed Apr 13, 2026 EDGAR ↗ ← All Funds
Q4 2025 Q3 2025 · All 21 New 14 Added 7 Reduced 10 Exited
Page 1 of 3  ·  54 positions
# Ticker Company Sector Shares Value ↓ % Port Chg Shares Chg % Period Price ① Since Period ①
1 HROW HARROW HEALTH INC Healthcare 3,905,000.0 $191.3M 25.25% $49.00 -36.7%
2 LQDA LIQUIDIA CORPORATION Healthcare 2,435,000.0 $85.0M 11.21% -180K -6.9% $34.90 +71.1%
3 ETON PHARMACEUTICALS INC 2,860,000.0 $48.4M 6.38% $16.91
4 RYTM RHYTHM PHARMACEUTICALS INC Healthcare 330,000.0 $35.3M 4.66% -132K -28.5% $107.04 -18.0%
5 APOGEE THERAPEUTICS INC 388,257.0 $29.3M 3.87% +25K +6.9% $75.48
6 SANUWAVE HEALTH INC 981,267.0 $29.3M 3.86% $29.84
7 STOK STOKE THERAPEUTICS INC Healthcare 695,000.0 $22.1M 2.91% +13K +1.9% $31.74 -6.7%
8 OCUL OCULAR THERAPEUTIX INC Healthcare 1,595,000.0 $19.4M 2.56% $12.14 -33.4%
9 SLGL SOL GEL TECHNOLOGIES Healthcare 453,739.0 $19.1M 2.52% +249K +121.5% $42.14 +59.3%
10 CGON CG ONCOLOGY INC Healthcare 410,000.0 $17.0M 2.25% $41.52 +52.8%
11 TGTX TG THERAPEUTICS INC Healthcare 535,000.0 $15.9M 2.10% $29.81 +32.3%
12 DISC MEDICINE INC 200,000.0 $15.9M 2.10% +6K +3.2% $79.41
13 RZLT REZOLUTE INC Healthcare 6,287,156.0 $14.8M 1.96% +5.4M +595.9% $2.36 +32.8%
14 CRESCENT BIOPHARMA INC 1,178,300.0 $14.0M 1.84% NEW $11.86
15 ALKS ALKERMES PLC Healthcare 490,000.0 $13.7M 1.81% +40K +8.9% $27.98 +32.6%
16 ALPHA COGNITION INC 2,070,784.0 $13.5M 1.78% +2.0M +1698.5% $6.50
17 ANNX ANNEXON INC Healthcare 2,600,000.0 $13.1M 1.72% $5.02 -2.2%
18 EWTX EDGEWISE THERAPEUTICS INC Healthcare 500,000.0 $12.4M 1.64% $24.82 +28.2%
19 CDXS CODEXIS INC Healthcare 6,789,738.0 $11.1M 1.46% -6.0M -46.9% $1.63 +50.6%
20 PTGX PROTAGONIST THERAPEUTICS INC Healthcare 105,000.0 $9.2M 1.21% $87.34 +12.4%
Page 1 of 3  ·  54 positions

Period Price is the implied market price on the last day of the reporting period, calculated as reported value ÷ shares held. It is not the fund's purchase price or cost basis — the fund may have initiated or added to the position at any point during the quarter at a different price. Since Period shows the price change from that quarter-end snapshot to today's last price — it reflects stock movement after the report date, not the fund's actual return.

Sector Allocation
Healthcare 100.0%