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Portfolio (Quarterly) Guide ↗

Opaleye Management Inc.

· CIK 0001595855
13F Portfolio $758M AUM 54 positions Filed Apr 13, 2026 EDGAR ↗ ← All Funds
Q4 2025 Q3 2025 · All 21 New 14 Added 7 Reduced 10 Exited
Page 1 of 2  ·  21 positions
# Ticker Company Sector Shares Value ↓ % Port Chg Shares Chg % Period Price ① Since Period ①
1 CRESCENT BIOPHARMA INC 1,178,300.0 $14.0M 1.84% NEW $11.86
2 KPTI KARYOPHARM THERAPEUTICS INC Healthcare 930,000.0 $6.8M 0.90% NEW $7.36 +1.5%
3 JBIO JADE BIOSCIENCES INC Healthcare 427,608.0 $6.6M 0.87% NEW $15.43 +42.6%
4 URGN UROGEN PHARMA LTD Healthcare 268,423.0 $6.3M 0.83% NEW $23.42 +22.0%
5 CATX PERSPECTIVE THERAPEUTICS INC Healthcare 1,184,500.0 $5.0M 0.66% NEW $4.21 -13.8%
6 VYGR VOYAGER THERAPEUTICS INC Healthcare 1,196,904.0 $4.7M 0.62% NEW $3.93 -10.2%
7 RLMD RELMADA THERAPEUTICS INC Healthcare 935,000.0 $4.5M 0.60% NEW $4.83 +31.3%
8 TECX TECTONIC THERAPEUTICS INC Healthcare 214,747.0 $4.5M 0.59% NEW $20.86 +32.8%
9 FORTRESS BIOTECH INC 1,090,000.0 $4.0M 0.53% NEW $3.66
10 RCKT ROCKET PHARMACEUTICALS INC Healthcare 955,000.0 $3.4M 0.44% NEW $3.51 -12.5%
11 MGTX MEIRAGTX HOLDINGS PLC Healthcare 390,844.0 $3.1M 0.41% NEW $7.95 +18.2%
12 ASRT ASSERTIO HOLDINGS INC Healthcare 285,000.0 $2.6M 0.34% NEW $9.07 +158.1%
13 VENTYX BIOSCIENCES INC 251,932.0 $2.3M 0.30% NEW $9.03
14 SUTRO BIOPHARMA INC 190,671.0 $2.2M 0.29% NEW $11.57
15 GENERATION BIO CO 310,000.0 $1.8M 0.23% NEW $5.68
16 BBIO BRIDGEBIO PHARMA INC Healthcare 18,319.0 $1.4M 0.18% NEW $76.49 -13.7%
17 ENTA ENANTA PHARMACEUTICALS INC Healthcare 75,000.0 $1.2M 0.16% NEW $15.77 -14.7%
18 QTTB Q32 BIO INC Healthcare 213,363.0 $708K 0.09% NEW $3.32 +82.8%
19 AVIR ATEA PHARMACEUTICALS INC Healthcare 179,815.0 $642K 0.09% NEW $3.57 +16.2%
20 SLN SILENCE THERAPEUTICS PLC Healthcare 78,926.0 $480K 0.06% NEW $6.08 +2.5%
Page 1 of 2  ·  21 positions

Period Price is the implied market price on the last day of the reporting period, calculated as reported value ÷ shares held. It is not the fund's purchase price or cost basis — the fund may have initiated or added to the position at any point during the quarter at a different price. Since Period shows the price change from that quarter-end snapshot to today's last price — it reflects stock movement after the report date, not the fund's actual return.

Sector Allocation
Healthcare 100.0%