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Portfolio (Quarterly) Guide ↗

Opaleye Management Inc.

· CIK 0001595855
13F Portfolio $707M AUM Filed Nov 14, 2025 EDGAR ↗ ← All Funds
Q4 2025 Q3 2025 · All 43 New
Page 1 of 3  ·  43 positions
# Ticker Company Sector Shares Value ↓ % Port Chg Shares Chg % Period Price ① Since Period ①
1 HROW HARROW HEALTH INC Healthcare 3,905,000.0 $188.1M 26.60% NEW $48.18 -35.9%
2 ETON PHARMACEUTICALS INC 2,860,000.0 $62.1M 8.79% NEW $21.73
3 LQDA LIQUIDIA CORPORATION Healthcare 2,615,000.0 $59.5M 8.41% NEW $22.74 +150.5%
4 RYTM RHYTHM PHARMACEUTICALS INC Healthcare 461,700.0 $46.6M 6.59% NEW $100.99 -14.0%
5 IMNM IMMUNOME INC Healthcare 3,185,000.0 $37.3M 5.27% NEW $11.71 +69.9%
6 SANUWAVE HEALTH INC 980,000.0 $36.7M 5.19% NEW $37.48
7 CDXS CODEXIS INC Healthcare 12,795,000.0 $31.2M 4.41% NEW $2.44 +0.8%
8 TGTX TG THERAPEUTICS INC Healthcare 535,000.0 $19.3M 2.73% NEW $36.12 +9.3%
9 OCUL OCULAR THERAPEUTIX INC Healthcare 1,595,000.0 $18.6M 2.64% NEW $11.69 -28.3%
10 CGON CG ONCOLOGY INC Healthcare 410,000.0 $16.5M 2.33% NEW $40.28 +57.1%
11 STOK STOKE THERAPEUTICS INC Healthcare 682,017.0 $16.0M 2.27% NEW $23.50 +23.5%
12 APOGEE THERAPEUTICS INC 363,257.0 $14.4M 2.04% NEW $39.73
13 ALKS ALKERMES PLC Healthcare 450,000.0 $13.5M 1.91% NEW $30.00 +23.3%
14 DISC MEDICINE INC 193,773.0 $12.8M 1.81% NEW $66.08
15 SRPT SAREPTA THERAPEUTICS INC Healthcare 585,000.0 $11.3M 1.59% NEW $19.27 -11.7%
16 LRMR LARIMAR THERAPEUTICS INC Healthcare 3,720,867.0 $10.6M 1.49% NEW $2.84 +14.1%
17 XOMA XOMA CORP DEL Healthcare 255,087.0 $9.8M 1.39% NEW $38.54 +8.0%
18 RZLT REZOLUTE INC Healthcare 903,442.0 $8.5M 1.20% NEW $9.40 -65.5%
19 ARVN ARVINAS INC Healthcare 987,818.0 $8.4M 1.19% NEW $8.52 +0.4%
20 EWTX EDGEWISE THERAPEUTICS INC Healthcare 500,000.0 $8.1M 1.15% NEW $16.22 +95.6%
Page 1 of 3  ·  43 positions

Period Price is the implied market price on the last day of the reporting period, calculated as reported value ÷ shares held. It is not the fund's purchase price or cost basis — the fund may have initiated or added to the position at any point during the quarter at a different price. Since Period shows the price change from that quarter-end snapshot to today's last price — it reflects stock movement after the report date, not the fund's actual return.

Sector Allocation
Healthcare 100.0%