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Portfolio (Quarterly) Guide ↗

Opaleye Management Inc.

· CIK 0001595855
13F Portfolio $758M AUM 54 positions Filed Apr 13, 2026 EDGAR ↗ ← All Funds
Q4 2025 Q3 2025 · All 21 New 14 Added 7 Reduced 10 Exited
Page 3 of 3  ·  54 positions
# Ticker Company Sector Shares Value ↓ % Port Chg Shares Chg % Period Price ① Since Period ①
41 ASRT ASSERTIO HOLDINGS INC Healthcare 285,000.0 $2.6M 0.34% NEW $9.07 +158.1%
42 VENTYX BIOSCIENCES INC 251,932.0 $2.3M 0.30% NEW $9.03
43 OPUS GENETICS INC 1,120,000.0 $2.3M 0.30% +20K +1.8% $2.01
44 SUTRO BIOPHARMA INC 190,671.0 $2.2M 0.29% NEW $11.57
45 CABA CABALETTA BIO INC Healthcare 900,000.0 $2.0M 0.26% +91K +11.3% $2.19 +49.3%
46 ZNTL ZENTALIS PHARMACEUTICALS INC Healthcare 1,400,906.0 $1.9M 0.25% +1.1M +342.6% $1.35 +168.9%
47 GENERATION BIO CO 310,000.0 $1.8M 0.23% NEW $5.68
48 BBIO BRIDGEBIO PHARMA INC Healthcare 18,319.0 $1.4M 0.18% NEW $76.49 -13.7%
49 ENTA ENANTA PHARMACEUTICALS INC Healthcare 75,000.0 $1.2M 0.16% NEW $15.77 -14.7%
50 QTTB Q32 BIO INC Healthcare 213,363.0 $708K 0.09% NEW $3.32 +82.8%
51 AVIR ATEA PHARMACEUTICALS INC Healthcare 179,815.0 $642K 0.09% NEW $3.57 +16.2%
52 SLN SILENCE THERAPEUTICS PLC Healthcare 78,926.0 $480K 0.06% NEW $6.08 +2.5%
53 RAPT THERAPEUTICS INC 150,000.0 $213K 0.03% NEW $1.42
54 ADGM ADAGIO MED HLDGS INC Healthcare 18,444.0 $19K 0.00% -92K -83.3% $1.04 -19.7%
Page 3 of 3  ·  54 positions

Period Price is the implied market price on the last day of the reporting period, calculated as reported value ÷ shares held. It is not the fund's purchase price or cost basis — the fund may have initiated or added to the position at any point during the quarter at a different price. Since Period shows the price change from that quarter-end snapshot to today's last price — it reflects stock movement after the report date, not the fund's actual return.

Sector Allocation
Healthcare 100.0%