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Portfolio (Quarterly) Guide ↗

Siren, L.L.C.

· CIK 0002005245
13F Portfolio $4.9B AUM 119 positions Filed Aug 13, 2026 EDGAR ↗ ← All Funds
Q2 2026 · All 117 New
Page 2 of 6  ·  117 positions
# Ticker Company Sector Shares Value ↓ % Port Chg Shares Chg % Period Price ① Since Period ①
21 COGT Cogent Biosciences Inc Healthcare 1,859,279.0 $72.0M 1.46% NEW $38.70 -3.9%
22 RLAY Relay Therapeutics Inc Healthcare 3,650,000.0 $68.3M 1.38% NEW $18.71 +9.0%
23 TSHA Taysha Gene Therapies Inc Healthcare 9,846,579.0 $67.1M 1.36% NEW $6.81 -8.9%
24 DFTX Definium Therapeutics Inc Healthcare 1,419,493.0 $66.8M 1.35% NEW $47.04 -3.4%
25 STOK Stoke Therapeutics Inc Healthcare 1,995,347.0 $65.3M 1.32% NEW $32.72 -1.5%
26 Disc Medicine Inc 888,401.0 $65.0M 1.31% NEW $73.14
27 CYTK Cytokinetics Inc Healthcare 758,952.0 $64.7M 1.31% NEW $85.19 -11.2%
28 SEPN Septerna Inc Healthcare 1,900,000.0 $63.6M 1.29% NEW $33.49 +31.7%
29 OLMA Olema Pharmaceuticals Inc Healthcare 4,856,949.0 $60.8M 1.23% NEW $12.51 -14.8%
30 CRNX Crinetics Pharmaceuticals Inc Healthcare 1,420,788.0 $53.2M 1.08% NEW $37.42 +126.6%
31 KLRA Kailera Therapeutics Inc Healthcare 2,214,286.0 $48.8M 0.99% NEW $22.03 -19.0%
32 DYN Dyne Therapeutics, Inc Healthcare 2,129,125.0 $47.3M 0.96% NEW $22.21 +16.0%
33 GPCR Structure Therapeutics Inc Healthcare 872,967.0 $46.9M 0.95% NEW $53.67 -1.1%
34 TBLA Taboola.com Ltd Communication Services 8,423,410.0 $42.1M 0.85% NEW $5.00 -23.6%
35 PVLA Palvella Therapeutics Inc Healthcare 257,485.0 $39.3M 0.80% NEW $152.82 -0.6%
36 SLN Silence Therapeutics PLC Healthcare 3,311,438.0 $36.4M 0.74% NEW $10.98 +26.2%
37 DNLI Denali Therapeutics Inc Healthcare 1,396,513.0 $35.9M 0.73% NEW $25.72 -5.9%
38 RELY Remitly Global Inc Technology 1,543,271.0 $34.6M 0.70% NEW $22.41 +17.5%
39 CGEM Cullinan Therapeutics Inc Healthcare 1,893,410.0 $34.5M 0.70% NEW $18.21 +13.0%
40 COF Capital One Finl Corp Financial Services 171,615.0 $34.4M 0.70% NEW $200.62 +10.7%
Page 2 of 6  ·  117 positions

Period Price is the implied market price on the last day of the reporting period, calculated as reported value ÷ shares held. It is not the fund's purchase price or cost basis — the fund may have initiated or added to the position at any point during the quarter at a different price. Since Period shows the price change from that quarter-end snapshot to today's last price — it reflects stock movement after the report date, not the fund's actual return.

Sector Allocation
Healthcare 92.4%
Technology 3.9%
Communication Services 1.8%
Financial Services 1.3%
Consumer Cyclical 0.6%
Real Estate 0.0%